Water → HCID 4738496, compound

HRID 2401161Notes

Reaction equation

HRID 2401161 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[C:4]([Cl:9])[N:3]=1.[Br:10]N1C(=O)CCC1=O.O>CN(C=O)C>[Br:10][C:7]1[C:2]([NH2:1])=[N:3][C:4]([Cl:9])=[N:5][C:6]=1[Cl:8]

Participants

5

Reactant 3

HCID 962WaterHCID 67184N-bromobutanimideHCID 823874-Pyrimidinamine, 2,6-dichloro-

Product 1

HCID 4738496HCID 4738496, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

2 g (12.2 mmol) of 4-amino-2,6-dichloropyrimidine were dissolved in 10 ml of DMF. To this solution were added 2.6 g (14.6 mmol) of N-bromosuccinimide. The reaction mixture was stirred at room temperature over night. The solution was poured onto 200 ml of cool water. The formed precipitate was filtered and washed with water. The product was obtained 2.7 g (91.9%) as a white powder.

Workup

  1. filtrationThe formed precipitate was filtered
  2. washwashed with water
  3. customThe product was obtained 2.7 g (91.9%) as a white powder

Sources & evidence

ORD record
ord-4de03cc8c7f84f919f4bbd7bfc7ec092
Source dataset
uspto-grants-2014_08
Patent number
US08796284B2

Reaction notes

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