Water → HCID 86677019, compound

HRID 2401165Notes

Reaction equation

HRID 2401165 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[C:4]([Cl:9])[N:3]=1.[I:10]N1C(=O)CCC1=O.O>CN(C=O)C>[Cl:9][C:4]1[N:3]=[C:2]([NH2:1])[C:7]([I:10])=[C:6]([Cl:8])[N:5]=1

Participants

5

Reactant 3

HCID 962WaterHCID 823874-Pyrimidinamine, 2,6-dichloro-HCID 120273N-Iodosuccinimide

Product 1

HCID 86677019HCID 86677019, compoundYield 76%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

1 g (6.1 mmol) of 4-amino-2,6-dichloropyrimidine were dissolved in 5 ml of DMF. To this solution was added 0.76 g (7.32 mmol) of N-Iodosuccinimide. The solution was stirred 18 h at room temperature and then poured onto 100 ml of cool water. The formed precipitate was filtered, washed with water and dried to yield 1.2 g (76%) of a pale yellow solid.

Workup

  1. filtrationThe formed precipitate was filtered
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-717b5f3d2da94b31ae79e4a2f02cc8e6
Source dataset
uspto-grants-2014_08
Patent number
US08796284B2

Reaction notes

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