Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | L-Valinol | HCID 640993 | — |
| Reactant | Carbamic acid, [6-(trifluoromethyl)-3-pyridinyl]-, phenyl ester | HCID 11173582 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | HCID 86705165 | HCID 86705165 | 113.3% |
Reaction Steps
Triethylamine (0.54 mL) and phenyl[6-(trifluoromethyl)pyridin-3-yl]carbamate (600 mg) were added to a solution of L-valinol (200 mg) in chloroform, and the mixture was stirred at 80° C. for 1 hr. The reaction mixture was concentrated under reduced pressure, and the residue was purified by column chromatography (silica gel cartridge, hexane/ethyl acetate) to afford 1-[(2S)-1-hydroxy-3-methylbutan-2-yl]-3-[6-(trifluoromethyl)pyridin-3-yl]urea (640 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08796272B2 |
|---|
| Source dataset | uspto-grants-2014_08 |
|---|
| ORD ID | ord-5a51699867224141a54c18f102344ac8 |
|---|
| Source note | uspto-grants-2014_08 |
|---|
