Hydrochloric Acid → HCID 178482252, compound

HRID 2401525Notes

Reaction equation

HRID 2401525 reaction equation
C(O[C:6](=O)[N:7](C)[CH:8]1[CH2:13][CH2:12][N:11]([C:14]2[N:22]=[CH:21][N:20]=[C:19]3[C:15]=2[N:16]=[CH:17][N:18]3C2CCCCO2)[CH2:10][CH2:9]1)(C)(C)C.Cl>C(O)C>[CH3:6][NH:7][CH:8]1[CH2:13][CH2:12][N:11]([C:14]2[N:22]=[CH:21][N:20]=[C:19]3[C:15]=2[N:16]=[CH:17][NH:18]3)[CH2:10][CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57899135HCID 57899135, compound

Product 1

HCID 178482252HCID 178482252, compoundYield 40%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of methyl-{1-[9-(tetrahydro-pyran-2-yl)-9H-purin-6-yl]-piperidin-4-yl}-carbamic acid tert-butyl ester (83 mg, 0.2 mmol), ethanol (4 ml) and 1M aqueous HCl solution (1 ml) was stirred overnight at room temperature. The solvents were then evaporated in vacuo and the crude product was purified with a flash NH2 column (2 g, 15 ml) eluting with methanol to afford the required compound (18 mg, 0.08 mmol, 39%) LC-MS (LCT) Rt 1.27 [M+H]+] 233.

Workup

  1. customThe solvents were then evaporated in vacuo
  2. customthe crude product was purified with a flash NH2 column (2 g, 15 ml)
  3. washeluting with methanol

Sources & evidence

ORD record
ord-c8234cf2ab8443fba419eb52fb24e87d
Source dataset
uspto-grants-2014_08
Patent number
US08796293B2

Reaction notes

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