Hydrogen Bromide → HCID 22499224, compound

HRID 2401588Notes

Reaction equation

HRID 2401588 reaction equation
[BrH:1].[OH:2][C:3]1[CH:4]=[C:5]([CH3:14])[CH:6]=[C:7]2[C:12]=1[NH:11][C:10](=[O:13])[CH:9]=[CH:8]2>C(O)(=O)C.CS(C)=O>[Br:1][C:6]1[C:5]([CH3:14])=[CH:4][C:3]([OH:2])=[C:12]2[C:7]=1[CH:8]=[CH:9][C:10](=[O:13])[NH:11]2

Participants

5

Reactant 2

HCID 260Hydrogen BromideHCID 22499171HCID 22499171, compound

Product 1

HCID 22499224HCID 22499224, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 679Dimethyl SulfoxideSolvent

Procedure

A 45% solution of hydrobromic acid in acetic acid (324 μL) is added dropwise to a solution of 8-hydroxy-6-methyl-1H-quinolin-2-one (316 mg) in dimethylsulphoxide (9 mL) at room temperature. The reaction mixture is allowed to stand for 18 hours at room temperature and the solvent removed in vacuo.

Workup

  1. customthe solvent removed in vacuo

Sources & evidence

ORD record
ord-c8005a98a1684c7c95d586955cba958c
Source dataset
uspto-grants-2014_08
Patent number
US08796307B2

Reaction notes

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