反应详情

130 g of 3-(cyclohexylmethoxy)pyridine-2-amine (Example 4A; 630 mmol, 1 equivalent) were initially charged in 3950 ml of ethanol, and 436 ml of ethyl 2-chloroacetoacetate (3.2 mol, 5 equivalents) were added. The resulting reaction mixture was heated under reflux for 24 h and then concentrated under reduced pressure. The crude product obtained in this manner was chromatographed on silica gel using cyclohexane/diethyl ether as mobile phase, giving 66.2 g (33.2% of theory) of the title compound.

1. customThe resulting reaction mixture
2. temperaturewas heated
3. temperatureunder reflux for 24 h
4. concentrationconcentrated under reduced pressure
5. customThe crude product obtained in this manner
6. customwas chromatographed on silica gel