Hydrochloric Acid → Methyl 3-amino-4,4,4-trifluorobutanoate--hydrogen chloride (1/1)

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Reaction Steps

1.5 g of 3-amino-4,4,4-trifluorobutanoic acid (9.55 mmol, 1 equivalent) were initially charged in 18 ml of methanol which had been saturated with hydrogen chloride, and the mixture was stirred under reflux for 4 h. The reaction solution was then concentrated, evaporated repeatedly with dichloromethane and dried under reduced pressure. This gave 1.86 g (94% of theory) of the title compound.

Provenance & Evidence