Hydrochloric Acid → Methyl 3-amino-4,4,4-trifluorobutanoate--hydrogen chloride (1/1)

HRID 2401643Notes

Reaction equation

HRID 2401643 reaction equation
[NH2:1][CH:2]([C:7]([F:10])([F:9])[F:8])[CH2:3][C:4]([OH:6])=[O:5].[ClH:11].[CH3:12]O>>[ClH:11].[NH2:1][CH:2]([C:7]([F:10])([F:9])[F:8])[CH2:3][C:4]([O:6][CH3:12])=[O:5]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 3429703-Amino-4,4,4-trifluorobutanoic acid

Product 1

HCID 44717682Methyl 3-amino-4,4,4-trifluorobutanoate--hydrogen chloride (1/1)

Procedure

1.5 g of 3-amino-4,4,4-trifluorobutanoic acid (9.55 mmol, 1 equivalent) were initially charged in 18 ml of methanol which had been saturated with hydrogen chloride, and the mixture was stirred under reflux for 4 h. The reaction solution was then concentrated, evaporated repeatedly with dichloromethane and dried under reduced pressure. This gave 1.86 g (94% of theory) of the title compound.

Workup

  1. temperatureunder reflux for 4 h
  2. concentrationThe reaction solution was then concentrated
  3. customevaporated repeatedly with dichloromethane
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-2af68bb6432f48898e02e28e98046c54
Source dataset
uspto-grants-2014_08
Patent number
US08796305B2

Reaction notes

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