Hydrochloric Acid → Methyl 2-amino-4,4,4-trifluorobutanoate hydrochloride

HRID 2401644Notes

Reaction equation

HRID 2401644 reaction equation
[ClH:1].[NH2:2][CH:3]([CH2:7][C:8]([F:11])([F:10])[F:9])[C:4]([OH:6])=[O:5].Cl.[CH3:13]O>>[ClH:1].[NH2:2][CH:3]([CH2:7][C:8]([F:11])([F:10])[F:9])[C:4]([O:6][CH3:13])=[O:5]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 27565662-Amino-4,4,4-trifluorobutanoic acid hydrochloride

Product 1

HCID 44717559Methyl 2-amino-4,4,4-trifluorobutanoate hydrochloride

Procedure

1.186 g (6.127 mmol) of 2-amino-4,4,4-trifluorobutanoic acid hydrochloride (1:1) were initially charged in 11.6 ml of methanol which had been saturated with hydrogen chloride, and the mixture was stirred under reflux for 4 h. The reaction solution was concentrated and dried under high vacuum. This gave 1.275 g of the target compound (100% of theory).

Workup

  1. temperatureunder reflux for 4 h
  2. concentrationThe reaction solution was concentrated
  3. customdried under high vacuum

Sources & evidence

ORD record
ord-e915e91fcac34e95b7e2c75667c30552
Source dataset
uspto-grants-2014_08
Patent number
US08796305B2

Reaction notes

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