Potassium Hydroxide → HCID 11254763, compound

HRID 2401964Notes

Reaction equation

HRID 2401964 reaction equation
Cl[C:2]1[C:10]2[C:6](=[N:7][O:8][N:9]=2)[C:5]([N+:11]([O-:13])=[O:12])=[CH:4][CH:3]=1.[SH:14][C:15]1[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=1.P([O-])([O-])([O-])=O.[K+].[K+].[K+].[OH-].[K+].BrCC(=O)C([O-])=O>C(O)C>[N+:11]([C:5]1[C:6]2=[N:7][O:8][N:9]=[C:10]2[C:2]([S:14][C:15]2[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=2)=[CH:3][CH:4]=1)([O-:13])=[O:12]

Participants

7

Reactant 5

HCID 14797Potassium HydroxideHCID 25043NBD-ClHCID 62657Potassium Phosphate, TribasicHCID 2401474-Mercaptophenol2×HCID 6994776Propanoic acid, 3-bromo-2-oxo-, ion(1-)

Product 1

HCID 11254763HCID 11254763, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixed solution of 4-chloro-7-nitro-2,1,3-benzoxadiazole (1 mmole) and 4-mercaptophenol (Sigma-Aldrich, Fine Chemicals) (2 mmoles) was made to react in 20 ml of ethanol: 1:1 potassium phosphate buffer, at pH 7.0 for 6 hours in a closed beaker, at 25° C. The pH was kept neutral by adding small quantities of KOH. At the end of the reaction, the excess 4-mercaptophenol was made to react with 1.5 mmoles of 3-bromopyruvate.

Workup

  1. customat 25° C
  2. customAt the end of the reaction

Sources & evidence

ORD record
ord-779e70cf1aa34e2fbd05992db463de39
Source dataset
uspto-grants-2014_08
Patent number
US08796317B2

Reaction notes

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