反应详情

温度

40 °C

A solution of aniline 2,5 disulphonic acid (27.5 g) in water (250 ml) was added to intermediate E (63.2 g) in acetonitrile (800 ml) and heated at 40° C. and at pH 5 to 7 overnight. The reaction solvent was removed under reduced pressure, water (50 ml) was added and then brine (60 ml) the solid which precipitated of filtered off, washed with 10% brine and dried to give product (91.1% strength, 22 g).

1. customThe reaction solvent was removed under reduced pressure, water (50 ml)
2. additionwas added
3. custombrine (60 ml) the solid which precipitated
4. filtrationof filtered off
5. washwashed with 10% brine
6. customdried
7. customto give product (91.1% strength, 22 g)