Water → HCID 2774444, compound

HRID 2402285Notes

Reaction equation

HRID 2402285 reaction equation
[F:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][NH2:7])=[CH:4][CH:3]=1.[C:10]1(=O)[O:15][C:13](=[O:14])[C:12]2=[CH:16][CH:17]=[CH:18][CH:19]=[C:11]12.O>C(Cl)Cl.C(O)(=O)C>[F:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][N:7]2[C:13](=[O:14])[C:12]3[C:11](=[CH:19][CH:18]=[CH:17][CH:16]=3)[C:10]2=[O:15])=[CH:4][CH:3]=1

Participants

6

Reactant 3

HCID 962WaterHCID 6811Phthalic AnhydrideHCID 673264-Fluorobenzylamine

Product 1

HCID 2774444HCID 2774444, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 6344DichloromethaneSolvent

Procedure

4-Fluorobenzylamine (20 g, 160 mmol) in 10 mL CH2Cl2 was added to phthalic anhydride (5 g, 34 mmol) in 20 mL glacial acetic acid. The reaction was stirred at 100° C. for 4 h as water was collected with a Dean-Stark trap. Solvent was evaporated and the product was obtained by crystallization from ethanol (7.5 g, 87%).

Workup

  1. customwas collected with a Dean-Stark trap
  2. customSolvent was evaporated
  3. customthe product was obtained by crystallization from ethanol (7.5 g, 87%)

Sources & evidence

ORD record
ord-7f56e73cb6a147fa91692eaaa09cd62c
Source dataset
uspto-grants-2014_08
Patent number
US08796313B2

Reaction notes

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