反应详情

4-Methylpentanoyl chloride (3.0 g, 22.3 mmol) was added dropwise to phenol (2.1 g, 22.3 mmol). After 3 hours, H2O was added and the reaction mixture was extracted with Et2O. The organic phase was washed with NaHCO3, then brine to neutrality, then dried (Na2SO4), concentrated and bulb-to-bulb distilled to afford the title compound in 88% yield.

1. extractionthe reaction mixture was extracted with Et2O
2. washThe organic phase was washed with NaHCO3
3. dry with materialbrine to neutrality, then dried (Na2SO4)
4. concentrationconcentrated
5. distillationbulb-to-bulb distilled