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Phenol → Phenyl 4-methylpentanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phenol | HCID 996 | — |
| 反応物 | Pentanoyl chloride, 4-methyl- | HCID 170008 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Phenyl 4-methylpentanoate | HCID 12653656 | 88% |
反応手順
4-Methylpentanoyl chloride (3.0 g, 22.3 mmol) was added dropwise to phenol (2.1 g, 22.3 mmol). After 3 hours, H2O was added and the reaction mixture was extracted with Et2O. The organic phase was washed with NaHCO3, then brine to neutrality, then dried (Na2SO4), concentrated and bulb-to-bulb distilled to afford the title compound in 88% yield.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08648032B2 |
| 出典データセット | uspto-grants-2014_02 |
| ORD ID | ord-2fdca11ac0de4538881cd3f7ef310dc2 |
| 出典メモ | uspto-grants-2014_02 |