Hydrochloric Acid → HCID 66672055, compound

HRID 2402824Notes

Reaction equation

HRID 2402824 reaction equation
[OH:1][CH2:2][CH2:3][CH:4]([NH:13]C(=O)OC(C)(C)C)[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[O:11][CH3:12].[ClH:21]>ClCCl.O1CCOCC1>[ClH:21].[NH2:13][CH:4]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[O:11][CH3:12])[CH2:3][CH2:2][OH:1]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 59536731HCID 59536731, compound

Product 1

HCID 66672055HCID 66672055, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

Of the compound from Example 172A, 100 mg (0.36 mmol) were dissolved in 2 ml of dichloromethane, and 1.63 ml (6.52 mmol) of a 4M solution of hydrogen chloride in dioxane were added. The yellow solution was subsequently stirred at RT for 1 h. The reaction mixture was evaporated to dryness on a rotary evaporator and dried in an HV. This gave 88 mg (100% of theory) of the title compound.

Workup

  1. customThe reaction mixture was evaporated to dryness on a rotary evaporator
  2. customdried in an HV

Sources & evidence

ORD record
ord-97dce841022e47cc9f0baf1137b5cf7d
Source dataset
uspto-grants-2014_08
Patent number
US08796324B2

Reaction notes

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