反应详情

Of the compound from Example 176A, 1.27 g (3.49 mmol), were introduced in 200 ml of methanol and 100 ml of water. Then 6.98 ml (6.98 mmol) of 1M aqueous lithium hydroxide solution were added. The mixture was stirred at RT for 2 h. For purification, 15 ml of 1N hydrochloric acid were added and the mixture was freed from methanol on a rotary evaporator. The residue was diluted with 100 ml of water and extracted three times with ethyl acetate. The combined organic phases were dried over sodium sulphate, filtered and freed from the solvent on a rotary evaporator, and dried in an HV. This gave 1.11 g (91% of theory) of the title compound.

1. customFor purification, 15 ml of 1N hydrochloric acid
2. additionwere added
3. customthe mixture was freed from methanol on a rotary evaporator
4. additionThe residue was diluted with 100 ml of water
5. extractionextracted three times with ethyl acetate
6. dry with materialThe combined organic phases were dried over sodium sulphate
7. filtrationfiltered
8. customfreed from the solvent on a rotary evaporator
9. customdried in an HV