Trifluoroacetic acid → HCID 89388365, compound

HRID 2402954Notes

Reaction equation

HRID 2402954 reaction equation
C[O:2][CH:3](OC)[C:4]1[CH:5]=[C:6]([CH:34]=[CH:35][CH:36]=1)[C:7]([C:9]1[C:14]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:13][N:12]=[C:11]([NH:20][C:21]2[CH:26]=[CH:25][C:24]([N:27]3[CH2:32][CH2:31][N:30]([CH3:33])[CH2:29][CH2:28]3)=[CH:23][CH:22]=2)[N:10]=1)=[O:8].C(O)(C(F)(F)F)=O>ClCCl>[CH:3]([C:4]1[CH:5]=[C:6]([CH:34]=[CH:35][CH:36]=1)[C:7]([C:9]1[C:14]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:13][N:12]=[C:11]([NH:20][C:21]2[CH:22]=[CH:23][C:24]([N:27]3[CH2:28][CH2:29][N:30]([CH3:33])[CH2:31][CH2:32]3)=[CH:25][CH:26]=2)[N:10]=1)=[O:8])=[O:2]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 89388363HCID 89388363, compound

Product 1

HCID 89388365HCID 89388365, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
40 °C

Procedure

A solution of Example 215B (200 mg, 0.54 mmol) in dichloromethane (20 ml) was added TFA (5 mL). The mixture was stirred at 40° C. overnight. The reaction mixture was concentrated and the crude product was used in the next step without further purification. MS (DCI/NH3) m/z 474 (M+H)+.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customthe crude product was used in the next step without further purification

Sources & evidence

ORD record
ord-d887a6d53af2459b9b1c8985ce824bb1
Source dataset
uspto-grants-2014_08
Patent number
US08796289B2

Reaction notes

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