HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dioxane → Ethyl 4-formyl-2-(methylthio)pyrimidine-5-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | Ethyl-2-methylthio-4-methyl-5-pyrimidine carboxylate | HCID 188208 | — |
| Product | Ethyl 4-formyl-2-(methylthio)pyrimidine-5-carboxylate | HCID 86676023 | — |
Reaction Steps
A solution of ethyl 4-methyl-2-(methylthio)pyrimidine-5-carboxylate in dioxane (330 mg, 1.56 mmol) was treated with SeO2 (220 mg, 2.0 mmol) at 100° C. for 3 days. After cooling, the reaction mixture was concentrated and the residue was purified by flash chromatography (20% ethyl acetate in hexane) to provide the title compound. MS (DCI/NH3) m/z 227 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08796289B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-1de5630cbcd641a2b711f9f37af559a0 |
| Source note | uspto-grants-2014_08 |