HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 9-hydroxy-3-methoxy-9H-indeno[1,2-b]pyrazine-2-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | 9-oxo-9H-indeno(1,2-b)pyrazine-2,3-dicarbonitrile | HCID 292929 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Product | 9-hydroxy-3-methoxy-9H-indeno[1,2-b]pyrazine-2-carbonitrile | HCID 16065352 | 53% |
Reaction Conditions
| Temperature | 0 °C |
|---|
Reaction Steps
To a suspension of 1 (150 mg, 0.646 mmol) in MeOH (6.5 ml), cooled at 0° C., NaBH4 (24 mg, 0.646 mmol) was added. After 30 min, water (5 ml) was added, MeOH was evaporated and the residue was extracted with CH2Cl2 (3×5 ml). The organic layers were dried over Na2SO4, filtered and evaporated. EtOH was added and the precipitate was collected by filtration affording 2 (82 mg, 53%) as white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08648076B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-53bbcc47733a4da5a71f65262cc9e700 |
| Source note | uspto-grants-2014_02 |