HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 240308Generated: October 26, 2026
Sodium Sulfate → 3-amino-9-oxo-9H-indeno[1,2-b]pyrazine-2-carbonitrile
https://huagongshe.com/reaction/240308
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Sulfate | HCID 24436 | — |
| Reactant | 9-oxo-9H-indeno(1,2-b)pyrazine-2,3-dicarbonitrile | HCID 292929 | — |
| Reactant | Ammonium Acetate | HCID 517165 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-amino-9-oxo-9H-indeno[1,2-b]pyrazine-2-carbonitrile | HCID 16065357 | 90% |
Reaction Steps
A mixture of 1 (201 mg, 0.86 mmol), ammonium acetate (331 mg, 4.3 mmol) and Na2SO4 (200 mg) in THF (2.9 ml) was stirred at 70° C. in sealed tube for 18 hours. The solvent was evaporated, water (5 ml) was added and the precipitate filtered, washed with water and dried under vacuum, affording 7 (171 mg, 90%) as green solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08648076B2 |
|---|
| Source dataset | uspto-grants-2014_02 |
|---|
| ORD ID | ord-cbcbdab1543444ab9d69875510961707 |
|---|
| Source note | uspto-grants-2014_02 |
|---|
