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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2403155Generated: October 26, 2026

Pyrrolidine → 1-(Pyrrolidin-1-yl)cyclopropanecarbonitrile

https://huagongshe.com/reaction/2403155

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPyrrolidineHCID 31268—
ReactantTrimethylsilyl cyanideHCID 82115—
Reactant(1-Ethoxycyclopropoxy)trimethylsilaneHCID 2734686—
ReactantEthylacetate heptaneHCID 21899848—
SolventEthyl AcetateHCID 8857—
Product1-(Pyrrolidin-1-yl)cyclopropanecarbonitrileHCID 22325146—

Reaction Steps

The reaction of (1-ethoxycyclopropoxy)trimethylsilane 13 and pyrrolidine 14D with trimethylsilylcyanide yielded after column chromatography with a gradient of heptane/ethyl acetate (v:v 4:1) to ethyl acetate as solvent 1-(pyrrolidin-1-yl)cyclopropanecarbonitrile as a yellow oil (quant.).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08802665B2
Source datasetuspto-grants-2014_08
ORD IDord-a426fd4d7e404adf9e1831a8b55033dc
Source noteuspto-grants-2014_08