HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 2,4-dibromobutanoate → Methyl 1-(4,4-difluorocyclohexyl)azetidine-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 2,4-dibromobutanoate | HCID 296716 | — |
| Reactant | 4,4-Difluorocyclohexan-1-amine hydrochloride | HCID 23150669 | — |
| Product | Methyl 1-(4,4-difluorocyclohexyl)azetidine-2-carboxylate | HCID 86692750 | 30% |
Reaction Steps
The reaction of methyl 2,4-dibromobutanoate 17 with 4,4-difluorocyclohexylamine hydrochloride 18B yielded methyl 1-(4,4-difluorocyclohexyl)azetidine-2-carboxylate as a brown oil (30%). MS ISP (m/e): 234.1 (100) [(M+H)]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08802665B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-462d06a9dcc74a53b5a3ef529252163a |
| Source note | uspto-grants-2014_08 |