Methyl 2,4-dibromobutanoate → HCID 86692752, compound

HRID 2403159Notes

Reaction equation

HRID 2403159 reaction equation
Br[CH:2]([CH2:7][CH2:8]Br)[C:3]([O:5][CH3:6])=[O:4].[NH2:10][CH:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1>>[CH3:6][O:5][C:3]([CH:2]1[CH2:7][CH2:8][N:10]1[CH:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1)=[O:4]

Participants

3

Reactant 2

HCID 296716Methyl 2,4-dibromobutanoateHCID 4192234-Aminotetrahydropyran

Product 1

HCID 86692752HCID 86692752, compoundYield 27%

Procedure

The reaction of methyl 2,4-dibromobutanoate 17 with 4-aminotetrahydropyran 18E yielded 1-(tetrahydro-pyran-4-yl)-azetidine-2-carboxylic acid methyl ester as a light yellow oil (27%). MS ISP (m/e): 200.2 (100) [(M+H)]+.

Sources & evidence

ORD record
ord-4dd1cc622ea946dbb3fc571ff0c71b2d
Source dataset
uspto-grants-2014_08
Patent number
US08802665B2

Reaction notes

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