Methyl 2,4-dibromobutanoate → HCID 86692754, compound

HRID 2403161Notes

Reaction equation

HRID 2403161 reaction equation
Br[CH:2]([CH2:7][CH2:8]Br)[C:3]([O:5][CH3:6])=[O:4].[CH3:10][C:11]1([CH3:18])[CH2:16][CH:15]([NH2:17])[CH2:14][CH2:13][O:12]1>>[CH3:10][C:11]1([CH3:18])[CH2:16][CH:15]([N:17]2[CH2:8][CH2:7][CH:2]2[C:3]([O:5][CH3:6])=[O:4])[CH2:14][CH2:13][O:12]1

Participants

3

Reactant 2

HCID 296716Methyl 2,4-dibromobutanoateHCID 38092032,2-dimethyltetrahydro-2H-pyran-4-amine

Product 1

HCID 86692754HCID 86692754, compoundYield 33%

Procedure

The reaction of methyl 2,4-dibromobutanoate 17 with 2,2-dimethyltetrahydro-2H-pyran-4-amine 18H yielded methyl 1-(2,2-dimethyltetrahydro-2H-pyran-4-yl)azetidine-2-carboxylate as a light brown solid (33%). MS ISP (m/e): 228.3 (100) [(M+H)]+.

Sources & evidence

ORD record
ord-c70271c1f3724241a696d6ded8706bea
Source dataset
uspto-grants-2014_08
Patent number
US08802665B2

Reaction notes

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