HCID 86675734, compound → HCID 86675733, compound

HRID 2403248Notes

Reaction equation

HRID 2403248 reaction equation
[NH2:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][NH:9][C:10](=[O:26])[NH:11][CH2:12][C:13]([N:15]([O:18]CC2C=CC=CC=2)[CH2:16][CH3:17])=[O:14])=[CH:4][CH:3]=1>CO.[Pd]>[NH2:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][NH:9][C:10](=[O:26])[NH:11][CH2:12][C:13]([N:15]([OH:18])[CH2:16][CH3:17])=[O:14])=[CH:4][CH:3]=1

Participants

4

Reactant 1

HCID 86675734HCID 86675734, compound

Product 1

HCID 86675733HCID 86675733, compoundYield 57%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 98 (38 mg) in MeOH (10 ml) was stirred for 1 h under hydrogen atmosphere in the presence of 10% Pd/C. The resulting mixture was filtered through celite and the filtrate was evaporated under reduced pressure to give 181 as white solid (16 mg, 57%). ESI-MS m/z: 268.1 [M+H]+.

Workup

  1. filtrationThe resulting mixture was filtered through celite
  2. customthe filtrate was evaporated under reduced pressure

Sources & evidence

ORD record
ord-9dcabe7a0b7f463fba153648514f26be
Source dataset
uspto-grants-2014_08
Patent number
US08802666B2

Reaction notes

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