HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 57443709, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-(5,6-Dichloro-2-methylamino-pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester | HCID 57443703 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 57443709 | HCID 57443709 | 100% |
Reaction Steps
2.6 g (7.2 mmol) 4-(5,6-dichloro-2-methylamino-pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester was deprotected at 10° C. using 100 ml ethylacetate saturated with gaseous hydrochloric acid. After 4 hours the precipitate was filtered giving the title compound (2.4 g, 100%), melting at 204-209° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08802672B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-4296734c163e42e7bcee34af394c9516 |
| Source note | uspto-grants-2014_08 |