Hydrochloric Acid → HCID 57443709, compound

HRID 2403265Notes

Reaction equation

HRID 2403265 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[C:19]([Cl:20])=[C:18]([Cl:21])[N:17]=[C:16]([NH:22][CH3:23])[N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:24]>C(OC(=O)C)C>[ClH:20].[ClH:24].[Cl:21][C:18]1[C:19]([Cl:20])=[C:14]([N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[N:15]=[C:16]([NH:22][CH3:23])[N:17]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 574437034-(5,6-Dichloro-2-methylamino-pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 57443709HCID 57443709, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

2.6 g (7.2 mmol) 4-(5,6-dichloro-2-methylamino-pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester was deprotected at 10° C. using 100 ml ethylacetate saturated with gaseous hydrochloric acid. After 4 hours the precipitate was filtered giving the title compound (2.4 g, 100%), melting at 204-209° C.

Workup

  1. customwas deprotected at 10° C.
  2. filtrationAfter 4 hours the precipitate was filtered

Sources & evidence

ORD record
ord-4296734c163e42e7bcee34af394c9516
Source dataset
uspto-grants-2014_08
Patent number
US08802672B2

Reaction notes

Loading…