HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 178482379, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 178482382 | HCID 178482382 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 178482379 | HCID 178482379 | 99% |
Reaction Steps
4.88 g (10 mmol) trans-(4-{2-[4-(5,6-dichloro-2-methylamino-pyrimidin-4-yl)-piperazin-1-yl]-ethyl}-cyclohexyl)-carbamic acid tert-butyl ester was deprotected at 10° C. using 100 ml ethylacetate saturated with gaseous hydrochloric acid. After 4 hours the precipitate was filtered giving the title compound (4.9 g, 99%), melting at 325-326° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08802672B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-7e389053b1304a9fb27673484c1c2c14 |
| Source note | uspto-grants-2014_08 |