反应详情

4.88 g (10 mmol) trans-(4-{2-[4-(5,6-dichloro-2-methylamino-pyrimidin-4-yl)-piperazin-1-yl]-ethyl}-cyclohexyl)-carbamic acid tert-butyl ester was deprotected at 10° C. using 100 ml ethylacetate saturated with gaseous hydrochloric acid. After 4 hours the precipitate was filtered giving the title compound (4.9 g, 99%), melting at 325-326° C.

1. customwas deprotected at 10° C.
2. filtrationAfter 4 hours the precipitate was filtered