Morpholine → HCID 66617699, compound

HRID 2403383Notes

Reaction equation

HRID 2403383 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([S:14](Cl)(=[O:16])=[O:15])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].C(N(CC)CC)C.[NH:25]1[CH2:30][CH2:29][O:28][CH2:27][CH2:26]1>ClCCl>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([S:14]([N:25]2[CH2:30][CH2:29][O:28][CH2:27][CH2:26]2)(=[O:16])=[O:15])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

5

Reactant 3

HCID 8083MorpholineHCID 8471TriethylamineHCID 45789737tert-Butyl 4-(chlorosulfonyl)piperidine-1-carboxylate

Product 1

HCID 66617699HCID 66617699, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 4-chlorosulfonyl-piperidine-1-carboxylic acid tert-butyl ester (295 mg) in dichloromethane stirring at 0° C. was added triethylamine (96 μL) and morpholine (55 μL). The reaction mixture was stirred overnight then quenched with water and extracted into dichloromethane. The combined organics were washed with brine and dried (MgSO4). The solvent was removed in vacuo to yield 4-(morpholine-4-sulfonyl)-piperidine-1-carboxylic acid tert-butyl ester (120 mg).

Workup

  1. customthen quenched with water
  2. extractionextracted into dichloromethane
  3. washThe combined organics were washed with brine
  4. dry with materialdried (MgSO4)
  5. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-b39feb85b8234d9b8628776320c16689
Source dataset
uspto-grants-2014_08
Patent number
US08802670B2

Reaction notes

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