1-((Trifluoromethyl)sulfonyl)piperazine → 2-Chloro-4-morpholin-4-yl-6-(4-trifluoromethanesulfonyl-piperazin-1-ylmethyl)-thieno[3,2-d]pyrimidine

HRID 2403388Notes

Reaction equation

HRID 2403388 reaction equation
[Cl:1][C:2]1[N:3]=[C:4]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)[C:5]2[S:10][C:9]([CH:11]=O)=[CH:8][C:6]=2[N:7]=1.[F:19][C:20]([F:31])([F:30])[S:21]([N:24]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1)(=[O:23])=[O:22]>>[Cl:1][C:2]1[N:3]=[C:4]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)[C:5]2[S:10][C:9]([CH2:11][N:27]3[CH2:26][CH2:25][N:24]([S:21]([C:20]([F:30])([F:31])[F:19])(=[O:22])=[O:23])[CH2:29][CH2:28]3)=[CH:8][C:6]=2[N:7]=1

Participants

3

Reactant 2

HCID 186908331-((Trifluoromethyl)sulfonyl)piperazineHCID 457899852-Chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde

Product 1

HCID 866192522-Chloro-4-morpholin-4-yl-6-(4-trifluoromethanesulfonyl-piperazin-1-ylmethyl)-thieno[3,2-d]pyrimidine

Procedure

Reaction between 2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidine-6-carbaldehyde and 1-trifluoromethanesulfonyl-piperazine using procedure C yielded 2-chloro-4-morpholin-4-yl-6-(4-trifluoromethanesulfonyl-piperazin-1-ylmethyl)-thieno[3,2-d]pyrimidine. This compound was subjected to procedure A to yield the desired final compound which was purified using flash chromatography

Sources & evidence

ORD record
ord-2e56d2fd61134e3583278e0aee52a2fe
Source dataset
uspto-grants-2014_08
Patent number
US08802670B2

Reaction notes

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