1-((Trifluoromethyl)sulfonyl)piperazine → 2-Chloro-4-morpholin-4-yl-6-(4-trifluoromethanesulfonyl-piperazin-1-ylmethyl)-thieno[3,2-d]pyrimidine

Participants

Role	Name	HCID	Charge
Reactant	1-((Trifluoromethyl)sulfonyl)piperazine	HCID 18690833	—
Reactant	2-Chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde	HCID 45789985	—
Product	2-Chloro-4-morpholin-4-yl-6-(4-trifluoromethanesulfonyl-piperazin-1-ylmethyl)-thieno[3,2-d]pyrimidine	HCID 86619252	—

Reaction Steps

Reaction between 2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidine-6-carbaldehyde and 1-trifluoromethanesulfonyl-piperazine using procedure C yielded 2-chloro-4-morpholin-4-yl-6-(4-trifluoromethanesulfonyl-piperazin-1-ylmethyl)-thieno[3,2-d]pyrimidine. This compound was subjected to procedure A to yield the desired final compound which was purified using flash chromatography

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08802670B2
Source dataset	uspto-grants-2014_08
ORD ID	ord-2e56d2fd61134e3583278e0aee52a2fe
Source note	uspto-grants-2014_08