Hydrochloric Acid → HCID 66617877, compound

HRID 2403401Notes

Reaction equation

HRID 2403401 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([S:14]([CH3:17])(=[O:16])=[O:15])[C:10]([CH3:19])([CH3:18])[CH2:9]1)=O)(C)(C)C.[ClH:20]>ClCCl.C(OCC)C>[ClH:20].[CH3:17][S:14]([N:11]1[CH2:12][CH2:13][NH:8][CH2:9][C:10]1([CH3:19])[CH3:18])(=[O:15])=[O:16]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 666177011,1-Dimethylethyl 3,3-dimethyl-4-(methylsulfonyl)-1-piperazinecarboxylate

Product 1

HCID 66617877HCID 66617877, compoundYield 75%

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

To a solution of 4-methanesulfonyl-3,3-dimethyl-piperazine-1-carboxylic acid tert-butyl ester (914 mg) in dichloromethane (20 mL) at 0° C. was added dropwise HCl (6.65 mL of a 2 M solution in diethyl ether). The reaction mixture was stirred at room temperature for 2 h. The precipitate formed was then collected by filtration and dried to afford 1-methanesulfonyl-2,2-dimethyl-piperazine hydrochloride salt as a white solid (540 mg, 75%).

Workup

  1. customThe precipitate formed
  2. filtrationwas then collected by filtration
  3. customdried

Sources & evidence

ORD record
ord-a523bd5de68c4212a1a9c93bebbf9e4c
Source dataset
uspto-grants-2014_08
Patent number
US08802670B2

Reaction notes

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