Hydrochloric Acid → HCID 86619264, compound

HRID 2403421Notes

Reaction equation

HRID 2403421 reaction equation
C(OC([N:8]1[CH2:12][CH2:11][CH2:10][CH:9]1[CH2:13][N:14]([CH2:16][C:17]1[S:25][C:24]2[C:23]([N:26]3[CH2:31][CH2:30][O:29][CH2:28][CH2:27]3)=[N:22][C:21]([Cl:32])=[N:20][C:19]=2[CH:18]=1)[CH3:15])=O)(C)(C)C.Cl>ClCCl.C(OCC)C>[ClH:32].[Cl:32][C:21]1[N:22]=[C:23]([N:26]2[CH2:27][CH2:28][O:29][CH2:30][CH2:31]2)[C:24]2[S:25][C:17]([CH2:16][N:14]([CH3:15])[CH2:13][CH:9]3[CH2:10][CH2:11][CH2:12][NH:8]3)=[CH:18][C:19]=2[N:20]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 86619263HCID 86619263, compound

Product 1

HCID 86619264HCID 86619264, compoundYield 182.4%

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

To a solution of 2-{[(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-methyl-amino]-methyl}-pyrrolidine-1-carboxylic acid tert-butyl ester (480 mg) in dichloromethane (10 mL) was added hydrogen chloride (3 mL of a 2.0 M solution in diethyl ether). The mixture was stirred at room temperature for 16 h and then reduced in vacuo to give (2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-methyl-pyrrolidin-2-ylmethyl-amine hydrochloride salt as a yellow solid (380 mg).

Sources & evidence

ORD record
ord-e80e17deeb494783a7fc876e45980b0d
Source dataset
uspto-grants-2014_08
Patent number
US08802670B2

Reaction notes

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