反应详情

To N—BOC-piperazine (1.3 g) in dry DCM (10 ml) was added triethylamine (1.2 mL) and cyclopropanesulphonyl chloride (1.04 g) and the reaction mixture was stirred at room temperature for 16 hours. The reaction mixture was then diluted with DCM, washed with water, dried (MgSO4) and reduced in vacuo. The residue was dissolved in methanol (10 mL) and 4M HCL in dioxane was added (20 mL). After stirring overnight the solvent was reduced in vacuo to yield 1-cyclopropanesulfonyl-piperazine hydrochloride.

1. washwashed with water
2. dry with materialdried (MgSO4)
3. dissolutionThe residue was dissolved in methanol (10 mL)
4. addition4M HCL in dioxane was added (20 mL)
5. stirringAfter stirring overnight the solvent