2-Chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde → 2-Chloro-6-(4-cyclopropanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine

HRID 2403443Notes

Reaction equation

HRID 2403443 reaction equation
[Cl:1][C:2]1[N:3]=[C:4]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)[C:5]2[S:10][C:9]([CH:11]=O)=[CH:8][C:6]=2[N:7]=1.Cl.[CH:20]1([S:23]([N:26]2[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)(=[O:25])=[O:24])[CH2:22][CH2:21]1>>[Cl:1][C:2]1[N:3]=[C:4]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)[C:5]2[S:10][C:9]([CH2:11][N:29]3[CH2:30][CH2:31][N:26]([S:23]([CH:20]4[CH2:22][CH2:21]4)(=[O:25])=[O:24])[CH2:27][CH2:28]3)=[CH:8][C:6]=2[N:7]=1

Participants

3

Reactant 2

HCID 457899852-Chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehydeHCID 666176371-(cyclopropylsulfonyl)piperazine hydrochloride

Product 1

HCID 866192722-Chloro-6-(4-cyclopropanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine

Procedure

2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidine-6-carbaldehyde was treated with 1-cyclopropanesulfonyl-piperazine hydrochloride using General Procedure C (reductive amination) to yield 2-chloro-6-(4-cyclopropanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine.

Sources & evidence

ORD record
ord-859f676f63fd4b229bec3e1a67d572de
Source dataset
uspto-grants-2014_08
Patent number
US08802670B2

Reaction notes

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