HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde → 2-Chloro-6-(4-cyclopropanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde | HCID 45789985 | — |
| Reactant | 1-(Cyclopropanesulfonyl)piperazine hydrochloride | HCID 66617637 | — |
| Product | 2-Chloro-6-(4-cyclopropanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine | HCID 86619272 | — |
Reaction Steps
2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidine-6-carbaldehyde was treated with 1-cyclopropanesulfonyl-piperazine hydrochloride using General Procedure C (reductive amination) to yield 2-chloro-6-(4-cyclopropanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08802670B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-859f676f63fd4b229bec3e1a67d572de |
| Source note | uspto-grants-2014_08 |