Hydrochloric Acid → HCID 56833848, compound

HRID 2403444Notes

Reaction equation

HRID 2403444 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][C:15]2[S:30][C:18]3[N:19]=[C:20]([Cl:29])[N:21]=[C:22]([N:23]4[CH2:28][CH2:27][O:26][CH2:25][CH2:24]4)[C:17]=3[CH:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>C(OCC)C>[Cl:29][C:20]1[N:21]=[C:22]([N:23]2[CH2:24][CH2:25][O:26][CH2:27][CH2:28]2)[C:17]2[CH:16]=[C:15]([CH2:14][N:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]3)[S:30][C:18]=2[N:19]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 56833847HCID 56833847, compound

Product 1

HCID 56833848HCID 56833848, compoundYield 71.7%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

4-(2-Chloro-4-morpholin-4-yl-thieno[2,3-d]pyrimidine-6-ylmethyl)-piperazine-1-carboxylic acid tert-butyl ester (1.61 g) was treated with an excess of hydrogen chloride in diethyl ether at room temperature overnight. Removal of volatiles and basification with aqueous sodium hydrogen chloride afforded 2-chloro-4-morpholin-4-yl-6-piperazin-1-ylmethyl-thieno[2,3-d]pyrimidine (0.90 g).

Workup

  1. customRemoval of volatiles and basification with aqueous sodium hydrogen chloride

Sources & evidence

ORD record
ord-b3ba5bef7e5744ceaaf59c7e7aabf363
Source dataset
uspto-grants-2014_08
Patent number
US08802670B2

Reaction notes

Loading…