Hydrochloric Acid → HCID 58539164, compound

HRID 2403468Notes

Reaction equation

HRID 2403468 reaction equation
Cl[C:2]1[N:7]=[C:6]([NH:8][CH3:9])[C:5]([F:10])=[CH:4][N:3]=1.[NH2:11][C:12]1[CH:20]=[CH:19][C:15]([C:16]([OH:18])=[O:17])=[CH:14][C:13]=1[O:21][CH3:22].Cl>O1CCOCC1>[F:10][C:5]1[C:6]([NH:8][CH3:9])=[N:7][C:2]([NH:11][C:12]2[CH:20]=[CH:19][C:15]([C:16]([OH:18])=[O:17])=[CH:14][C:13]=2[O:21][CH3:22])=[N:3][CH:4]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 2880572486-69-3HCID 50723072-chloro-5-fluoro-N-methylpyrimidin-4-amine

Product 1

HCID 58539164HCID 58539164, compoundYield 88.4%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
120 °C

Procedure

A mixture of 50 mg 2-chloro-5-fluoro-N-methylpyrimidin-4-amine, 57 mg 4-Amino-3-methoxybenzoic acid, 0.1 mL 4N HCl in 1,4-dioxane and 1 mL N-butanol was placed in a 10 mL snap-top microwave vial (CEM Corp.) and heated to 120° C. microwave for 40 min. The reaction was monitored by LC/MS. The precipitated solid was filtered to yield 80 mg of 4-(5-fluoro-4-(methylamino)pyrimidin-2-ylamino)-3-methoxybenzoic acid.

Workup

  1. filtrationThe precipitated solid was filtered

Sources & evidence

ORD record
ord-413ec00d1373433e8184f7c428c8edb4
Source dataset
uspto-grants-2014_08
Patent number
US08802674B2

Reaction notes

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