Water → HCID 68633648, compound

To (R)-1-(4-(benzyloxy)-5-methoxy-2-nitrobenzoyl)piperidine-2-carbaldehyde (1.0 g, 2.51 mmol) in a mixture solution of 25 ml of THF and 15 ml of water was added Na2S2O4 (3.0 g, 17.25 mmol). The mixture was stirred for 4 h, diluted with methanol and dioxane, evaporated and co-evaporated with dioxane (3×60 ml) to dryness. The solid was sonicated with a mixture of CH3OH/CH2Cl2 (1:1, 80 ml), filtered and evaporated to solid. The yield solid was dissolved in CH3OH (100 ml) and 0.4 ml of HCl (conc) was added. The mixture was stirred for 1 h, neutralized to pH 3.0 with 0.1 M NaHCO3, concentrated, and extracted with CH2Cl2 (4×60 ml), The organic layers were combined, washed with 1M NaHCO3/NaCl (conc.), dried over Na2SO4, filtered, evaporated and purified on SiO2 chromatography eluted with EtAc/CH2Cl2 (1:3) to afford 615 mg (70%) of the title product. 1H NMR (CDCl3), 7.81 (d, 1H, J=5.7 Hz), 7.38˜7.23 (m, 6H), 6.74 (s, 1H), 5.12 (dd, 2H, J=2.3, 21.8 Hz), 4.18 (m, 1H), 3.88 (d, 3H), 3.69 (m, 1H), 3.15 (m, 1H), 1.99 (m, 1H), 1.87 (m, 1H), 1.79˜1.65 (m, 4H); 13C NMR 167.76, 163.31, 150.72, 148.48, 140.09, 136.46, 128.87, 128.28, 127.53, 121.77, 111.01, 71.02, 56.41, 49.84, 39.93, 24.76, 23.21, 18.62; MS m/z+373.2 (M+Na), 391.2 (M+Na+H2O), 405.3 (M+Na+CH3OH).

1. customevaporated
2. customThe solid was sonicated with a mixture of CH3OH/CH2Cl2 (1:1, 80 ml)
3. filtrationfiltered
4. customevaporated to solid
5. dissolutionThe yield solid was dissolved in CH3OH (100 ml)
6. addition0.4 ml of HCl (conc) was added
7. stirringThe mixture was stirred for 1 h
8. concentrationconcentrated
9. extractionextracted with CH2Cl2 (4×60 ml)
10. washwashed with 1M NaHCO3/NaCl (conc.)
11. dry with materialdried over Na2SO4
12. filtrationfiltered
13. customevaporated
14. custompurified on SiO2 chromatography
15. washeluted with EtAc/CH2Cl2 (1:3)

ORD record

ord-1738b9d22fee49ac9159a0bc4b262347

Source dataset

uspto-grants-2014_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08802667B2