HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl 4-(2-fluoroethyl)piperazine-1-carboxylate → 1-(2-Fluoroethyl)piperazine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl 4-(2-fluoroethyl)piperazine-1-carboxylate | HCID 21082715 | — |
| Reactant | Hydrogen chloride-ethyl acetate | HCID 21866389 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 1-(2-Fluoroethyl)piperazine dihydrochloride | HCID 66545688 | — |
Reaction Steps
tert-Butyl 4-(2-fluoroethyl)piperazine-1-carboxylate (460 mg) was dissolved in EtOAc (5 ml), and 4 M hydrogen chloride/EtOAc (2.5 ml) was added thereto. After stirring at room temperature for 7 hours, the precipitated solid was collected by filtration to obtain 1-(2-fluoroethyl)piperazine dihydrochloride (406 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08802679B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-2ce8ac9a02a04dd496f33febd9fe258d |
| Source note | uspto-grants-2014_08 |