tert-Butyl 4-(2-fluoroethyl)piperazine-1-carboxylate → 1-(2-Fluoroethyl)piperazine dihydrochloride

HRID 2403568Notes

Reaction equation

HRID 2403568 reaction equation
[F:1][CH2:2][CH2:3][N:4]1[CH2:9][CH2:8][N:7](C(OC(C)(C)C)=O)[CH2:6][CH2:5]1.[ClH:17].CCOC(C)=O>CCOC(C)=O>[ClH:17].[ClH:17].[F:1][CH2:2][CH2:3][N:4]1[CH2:9][CH2:8][NH:7][CH2:6][CH2:5]1

Participants

4

Reactant 2

HCID 21082715tert-Butyl 4-(2-fluoroethyl)piperazine-1-carboxylateHCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 665456881-(2-Fluoroethyl)piperazine dihydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

tert-Butyl 4-(2-fluoroethyl)piperazine-1-carboxylate (460 mg) was dissolved in EtOAc (5 ml), and 4 M hydrogen chloride/EtOAc (2.5 ml) was added thereto. After stirring at room temperature for 7 hours, the precipitated solid was collected by filtration to obtain 1-(2-fluoroethyl)piperazine dihydrochloride (406 mg).

Workup

  1. filtrationthe precipitated solid was collected by filtration

Sources & evidence

ORD record
ord-2ce8ac9a02a04dd496f33febd9fe258d
Source dataset
uspto-grants-2014_08
Patent number
US08802679B2

Reaction notes

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