6-(4-((Tert-butoxy)carbonyl)piperazin-1-yl)pyridine-3-carboxylic acid → 1279027-16-5

HRID 2403572Notes

Reaction equation

HRID 2403572 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:22]=[CH:21][C:17]([C:18]([OH:20])=[O:19])=[CH:16][N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:23].O1CCOCC1>O1CCOCC1>[ClH:23].[ClH:23].[N:11]1([C:14]2[CH:22]=[CH:21][C:17]([C:18]([OH:20])=[O:19])=[CH:16][N:15]=2)[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

Participants

4

Reactant 2

HCID 27718236-(4-((Tert-butoxy)carbonyl)piperazin-1-yl)pyridine-3-carboxylic acidHCID 204431481,4-Dioxane hydrochloride

Product 1

HCID 866679691279027-16-5

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

6-[4-(tert-Butoxycarbonyl)piperazin-1-yl]nicotinic acid (934 mg) was dissolved in dioxane (12 ml), and 4 M hydrogen chloride/dioxane (7 ml) was added thereto, followed by stirring at room temperature overnight. The precipitated solid was collected by filtration to obtain 6-piperazin-1-yl nicotinic acid dihydrochloride (850 mg).

Workup

  1. filtrationThe precipitated solid was collected by filtration

Sources & evidence

ORD record
ord-8719bf3edd92439d99020cb7dc727709
Source dataset
uspto-grants-2014_08
Patent number
US08802679B2

Reaction notes

Loading…