HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-(4-((Tert-butoxy)carbonyl)piperazin-1-yl)pyridine-3-carboxylic acid → 1279027-16-5
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-(4-((Tert-butoxy)carbonyl)piperazin-1-yl)pyridine-3-carboxylic acid | HCID 2771823 | — |
| Reactant | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 1279027-16-5 | HCID 86667969 | — |
Reaction Steps
6-[4-(tert-Butoxycarbonyl)piperazin-1-yl]nicotinic acid (934 mg) was dissolved in dioxane (12 ml), and 4 M hydrogen chloride/dioxane (7 ml) was added thereto, followed by stirring at room temperature overnight. The precipitated solid was collected by filtration to obtain 6-piperazin-1-yl nicotinic acid dihydrochloride (850 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08802679B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-8719bf3edd92439d99020cb7dc727709 |
| Source note | uspto-grants-2014_08 |