反应详情

To 3-chloro-4-{4-[5-(3-{[glycyl(methyl)amino]methyl}phenyl)pyrimidin-2-yl]piperazin-1-yl}benzoic acid dihydrochloride (3.0 g) were added THF (30 ml) and H2O (15 ml). To this mixture was added 1 N sodium hydroxide (10.6 ml), followed by stirring for 30 minutes. The precipitated solid was filtered and washed with water. The obtained product was dried at 50° C. under reduced pressure to obtain 3-chloro-4-{4-[5-(3-{[glycyl(methyl)amino]methyl}phenyl)pyrimidin-2-yl]piperazin-1-yl}benzoic acid (2.1 g) as a colorless solid.

1. filtrationThe precipitated solid was filtered
2. washwashed with water
3. customThe obtained product was dried at 50° C. under reduced pressure