Hydrochloric Acid → HCID 178482326, compound

HRID 2403680Notes

Reaction equation

HRID 2403680 reaction equation
Cl.[CH3:2][NH:3][C:4]1[NH:8][C:7]2[CH:9]=[CH:10][C:11]([C:13]([O:15]C)=[O:14])=[CH:12][C:6]=2[N:5]=1>>[CH3:2][NH:3][C:4]1[NH:8][C:7]2[CH:9]=[CH:10][C:11]([C:13]([OH:15])=[O:14])=[CH:12][C:6]=2[N:5]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 178482327HCID 178482327, compound

Product 1

HCID 178482326HCID 178482326, compoundYield 90%

Procedure

3 N Aqueous hydrochloric acid (14 mL, 42 mmol) was added to methyl 2-(methylamino)-1H-benzo[d]imidazole-5-carboxylate (2.9 g, 14 mmol) and the reaction was stirred at reflux overnight. The reaction was concentrated to give the title compound (2.4 g, 90%) as a yellow solid. 1H NMR (400 MHz, CD3OD, δ): 7.96-8.00 (m, 2 H), 7.40 (d, J=8.4 Hz, 1 H), 3.10 (s, 3 H).

Workup

  1. temperatureat reflux overnight
  2. concentrationThe reaction was concentrated

Sources & evidence

ORD record
ord-cd9b53104bbf48df8b607ebe18a6ff5a
Source dataset
uspto-grants-2014_08
Patent number
US08802688B2

Reaction notes

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