2-[6-(Methylamino)-2-pyridyl]ethan-1-ol → 3-[5-[2-(6-Methylamino-pyridin-2-yl)-ethoxy]-indol-1-yl}-hexanoic acid ethyl ester
Reaction equation
[CH3:1][NH:2][C:3]1[N:8]=[C:7]([CH2:9][CH2:10][OH:11])[CH:6]=[CH:5][CH:4]=1.[CH2:12]([O:14][C:15](=[O:31])[CH2:16][CH:17]([N:21]1[C:29]2[C:24](=[CH:25][C:26](O)=[CH:27][CH:28]=2)[CH:23]=[CH:22]1)[CH2:18][CH2:19][CH3:20])[CH3:13]>>[CH2:12]([O:14][C:15](=[O:31])[CH2:16][CH:17]([N:21]1[C:29]2[C:24](=[CH:25][C:26]([O:11][CH2:10][CH2:9][C:7]3[CH:6]=[CH:5][CH:4]=[C:3]([NH:2][CH3:1])[N:8]=3)=[CH:27][CH:28]=2)[CH:23]=[CH:22]1)[CH2:18][CH2:19][CH3:20])[CH3:13]Participants
3
Procedure
The title compound was synthesized from 2-(6-methylamino-pyridin-2-yl)-ethanol and 3-(5-hydroxy-indol-1-yl)-hexanoic acid ethyl ester using the procedure described in Example 14, step (c), in 25% yield. The crude product was used in the next step without further purification.
Workup
- customThe crude product was used in the next step without further purification
Sources & evidence
- ORD record
- ord-e66a215461ab494fb55a2366a55c4ba4
- Source dataset
- uspto-grants-2005_02
- Patent number
- US06855722B2
Reaction notes
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