反应详情

To a solution of Ph3PCH3I (0.97 g) in toluene (5 mL), KN(TMS)2 (0.5M in toluene, 4.8 mL) was added dropwise at room temperature. After 10 min, the solution of 4-(5-bromo-2-chlorobenzyl)benzaldehyde (intermediate AL) (0.62 g) in toluene (2 mL) was added dropwise. After 2 h, aqueous NaHCO3 was added to quench the reaction, and the resulting mixture was extracted with ethyl acetate. The organic layers were combined, washed with brine, and dried over Na2SO4. The solvent was evaporated under reduced pressure, and the product was purified by column chromatography to obtain pure intermediate AM (0.5 g).

1. waitAfter 2 h
2. customto quench
3. customthe reaction
4. extractionthe resulting mixture was extracted with ethyl acetate
5. washwashed with brine
6. dry with materialdried over Na2SO4
7. customThe solvent was evaporated under reduced pressure
8. customthe product was purified by column chromatography
9. customto obtain pure intermediate