反应详情

A solution of 5-(3-pyridinyl)-4-pentyn-1-ol (4.99 g, 31.0 mmol) in acetic acid (150 mL) was hydrogenated over platinum (IV) oxide (1.4 g, 6.16 mmol) for 18 hours. The mixture was filtered through a Celite cartridge, washed through with acetic acid and evaporated in vacuo to give a yellow oil. This was loaded in methanol and eluted on an aminopropyl (NH2) cartridge (70 g) with methanol (400 ml). The solvent was evaporated in vacuo to give the title compound as a colourless oil which solidified after being under vacuum for 18 hours (7.4 g).

1. filtrationThe mixture was filtered through a Celite cartridge
2. washwashed through with acetic acid
3. customevaporated in vacuo
4. customto give a yellow oil
5. washeluted on an aminopropyl (NH2) cartridge (70 g) with methanol (400 ml)
6. customThe solvent was evaporated in vacuo