Trifluoroacetic acid → HCID 178494011, compound

HRID 2403881Notes

Reaction equation

HRID 2403881 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH3:8][CH:9]([O:11][C:12]1[N:20]=[C:19]2[C:15]([N:16]=[C:17]([O:27][CH3:28])[N:18]2C2CCCCO2)=[C:14]([NH2:29])[N:13]=1)[CH3:10]>CO>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH3:10][CH:9]([O:11][C:12]1[NH:13][C:14]([NH2:29])=[C:15]2[C:19]([N:20]=1)=[N:18][C:17]([O:27][CH3:28])=[N:16]2)[CH3:8]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acid2×HCID 592525842-[(1-Methylethyl)oxy]-8-(methyloxy)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine

Product 1

HCID 178494011HCID 178494011, compoundYield 65%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Trifluoroacetic acid (1 ml, 12.98 mmol) was added to a stirred solution of 2-[(1-methylethyl)oxy]-8-(methyloxy)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine (568 mg, 1.848 mmol) in methanol (10 ml) and the mixture was stirred at room temperature overnight. More trifluoroacetic acid (0.2 ml) was added and the reaction mixture stirred at room temperature for a further 1.5 hours and then evaporated in vacuo. The solid residue was triturated with ethyl acetate, collected by filtration, washed with ethyl acetate and dried in vacuo overnight to give the title compound as a white solid (405 mg).

Workup

  1. stirringthe reaction mixture stirred at room temperature for a further 1.5 hours
  2. customevaporated in vacuo
  3. customThe solid residue was triturated with ethyl acetate
  4. filtrationcollected by filtration
  5. washwashed with ethyl acetate
  6. customdried in vacuo overnight

Sources & evidence

ORD record
ord-a683ffb12995470ca850dce0d5e00616
Source dataset
uspto-grants-2014_08
Patent number
US08802684B2

Reaction notes

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